ANTAGONISM OF THE SPINAL ACTION OF DIAZEPAM BY SEMICARBAZIDE
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Open Access
- 1 May 1974
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 51 (1) , 101-103
Abstract
In spinal unanaesthetized cats, pretreatment with semicarbazide (200 mg/kg) 2–4.5 h prior to the administration of diazepam (1–4 mg/kg) completely blocked the enhancement of the segmental dorsal root reflex by the latter compound. Pyridoxine hydrochloride (200 mg/kg), given 3.5 h after semicarbazide, restored the spinal effect of diazepam administered 1 h later. The possibility of a link between diazepam and spinal γ-aminobutyric acid is suggested and discussed.Keywords
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