Chenodeoxycholic Acid as a Potential Prognostic Marker for Roux-en-Y Gastric Bypass in Chinese Obese Patients

Authors:
  • YNYan Ni
    Yan Ni
  • YBYuqian Bao
    Yuqian Bao
  • PZPin Zhang
    Pin Zhang
  • AZAihua Zhao
    Aihua Zhao
  • TCTianlu Chen
    Tianlu Chen
  • GXGuoxiang Xie
    Guoxiang Xie
  • YTYinfang Tu
    Yinfang Tu
  • LZLei Zhang
    Lei Zhang
  • MSMingming Su
    Mingming Su
  • LWLi Wei
    Li Wei
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Abstract
Context: Bile acids (BAs) have been suggested as key mediators of the improvements in glucose metabolism after Roux-en-Y gastric bypass (RYGB). Objective: To test whether the individual or a group of BAs have potential value to predict diabetes remission after RYGB. Design and Patients: A retrospective cohort of 38 Chinese obese patients with type 2 diabetes (T2DM) who had undergone RYGB and a cross-sectional cohort of 327 subjects from the Shanghai Obesity Study (SHOS) were involved in the study. Main Outcome and Measures: We applied a targeted metabolomics approach to quantitatively measure 26 serum BAs. The relative proportion of each BA in total BAs was calculated. Results: In the metabolic surgery study, RYGB was effective in the reduction of body weight in both remission and non-remission groups. The reductions of BMI in both groups were 7.34±2.10kg/m2 and 6.31±2.38kg/m2 respectively (p=0.14). Patients in the remission group had shorter duration of diabetes, lower glycated haemoglobin (HbA1c), highe...