3-(2-Chloroethoxy)-1-(4-methoxyphenyl)-1H-pyrazole-4-carbaldehyde
Open Access
Abstract
Herein, we describe the synthesis of 3-(2-chloroethoxy)-1-(4-methoxyphenyl)-1H-pyrazole-4-carbaldehyde via the Vilsmeier-Haack reaction. The structure of this previously unreported compound is thoroughly elucidated through NMR, FT-IR spectroscopy and HRMS spectrometry.Keywords
Funding Information
- Research Council of Lithuania (S-MIP-23-51)
This publication has 26 references indexed in Scilit:
- Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agentsEuropean Journal of Medicinal Chemistry, 2023
- Synthesis and photodynamic properties of pyrazole-indole hybrids in the human skin melanoma cell line G361Dyes and Pigments, 2020
- D–π–A‐Type Triazatruxene‐Based Dopant‐Free Hole Transporting Materials for Efficient and Stable Perovskite Solar CellsSolar RRL, 2020
- Biomolecular docking, synthesis, crystal structure, and bioassay studies of 1-[4-(2-chloroethoxy)phenyl]-5-[4-(methylsulfonyl)phenyl]-1H-tetrazole and 2-(4-(5-(4-(methylsulfonyl)phenyl)-1H-tetrazol-1-yl)phenoxy)ethyl nitrateJournal of Molecular Structure, 2020
- Synthesis and anti-mitotic activity of 2,4- or 2,6-disubstituted- and 2,4,6-trisubstituted-2H-pyrazolo[4,3-c]pyridinesEuropean Journal of Medicinal Chemistry, 2018
- Design, synthesis, biological evaluation and molecular docking studies of novel 3-aryl-4-anilino-2H-chromen-2-one derivatives targeting ERα as anti-breast cancer agentsBioorganic & Medicinal Chemistry Letters, 2017
- Organocatalytic asymmetric cross-aldol reaction of 2-chloroethoxy acetaldehyde: diversity-oriented synthesis of chiral substituted 1,4-dioxanes and morpholinesTetrahedron: Asymmetry, 2013
- Isolation of highly pure erlotinib hydrochloride by recrystallization after nucleophilic substitution of an impurity with piperazineResearch on Chemical Intermediates, 2012
- Triaryl (Z)-olefins suitable for radiolabeling with iodine-124 or fluorine-18 radionuclides for positron emission tomography imaging of estrogen positive breast tumorsBioorganic & Medicinal Chemistry Letters, 2011
- Cyclization of functionalized ketene-N,S-acetals to substituted pyrroles: applications in the synthesis of marine pyrrole alkaloidsTetrahedron Letters, 2005