‘More than devastating’—patient experiences and neurological sequelae of Japanese encephalitis§

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Abstract
Background: Japanese encephalitis (JE), caused by the mosquito-borne JE virus, is a vaccine-preventable disease endemic to much of Asia. Travellers from non-endemic areas are susceptible if they travel to a JE endemic area. Although the risk to travellers of JE is low, the consequences may be severe. Methods: Here, we describe three cases of JE in British travellers occurring in 2014–15. In addition, we report, through interviews with survivors and their families, personal experiences of life after JE. Results: Three cases of JE were diagnosed in British travellers in 2014/15. One was acquired in Thailand, one in China and one in either Thailand, Laos or Cambodia. All three patients suffered severe, life-threatening illnesses, all were admitted to intensive care units and required medical evacuation back to the UK. One patient suffered a cardiac arrest during the acute stage but made a good recovery. The other two patients remain significantly paralysed and ventilator dependent. All three cases had clear indications for vaccination, and all have been left with life-changing neurological sequelae. Conclusions: Travel health providers should be aware of the severity of JE, as well as the risk, allowing travellers to make fully informed decisions on JE vaccination.
Funding Information
  • National Institute for Health Research (RP-PG-0108-10,048)
  • Wellcome Trust (205228/Z/16/Z)
  • Department of Health or Public Health England
  • European Union Zika Pan Latin American Network
  • Horizon 2020 (734584)

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