Review Article Cytochromes P450 in fungi
Authors:
Abstract
Summary. The article gives an overview on the history of the discovery of P450 cytochromes and on their occurrence in nature, especially on their interactions with metabolic pathways in fungi. The significance of the P450 cytochromes in the ergosterol synthesis as well as in the inhibitory mechanisms caused by imidazole and triazole antimycotics is described is detail.Zusammenfassung. Der Artikel gibt eine Übersicht über die Entdeckungsgeschichte der P450‐Cytochrome und ihr Vorkommen in der Natur. Insbesondere wird eingegangen auf das Vorkommen der P450‐Cytochrome in Pilzen und ihre Interaktionen mit Stoffwechselprozessen der Pilzzellen. Die Bedeutung der P450‐Cytochrome für die Ergosterol‐Synthese der Pilze und für deren Hemmechanismen durch Imidazol‐ und Triazol‐Antimykotika wird im Detail dargestellt.Keywords
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