Efficiency and scalability in harvesting mammalian cell cultures: A scale-down approach to continuous centrifugation
Open Access
- 27 January 2026
- journal article
- Published by Elsevier in Journal of Biotechnology
- Vol. 411, 89-101
Abstract
No abstract availableKeywords
Funding Information
- VINNOVA (2022-03170)
- VINNOVA (2021-02640)
This publication has 28 references indexed in Scilit:
- Progression of continuous downstream processing of monoclonal antibodies: Current trends and challengesBiotechnology and Bioengineering, 2018
- Progress in biopharmaceutical developmentBiotechnology and Applied Biochemistry, 2017
- A scale‐down mimic for mapping the process performance of centrifugation, depth and sterile filtrationBiotechnology and Bioengineering, 2016
- A novel approach to monitor clearance of host cell proteins associated with monoclonal antibodiesBiotechnology Progress, 2014
- Process cost and facility considerations in the selection of primary cell culture clarification technologyBiotechnology Progress, 2013
- The dynamics of the CHO host cell protein profile during clarification and protein A capture in a platform antibody purification processBiotechnology and Bioengineering, 2012
- Modeling industrial centrifugation of mammalian cell culture using a capillary based scale‐down systemBiotechnology and Bioengineering, 2010
- Evaluation of the effect of chronic hydrodynamical stresses on cultures of suspensed CHO‐6E6 cellsBiotechnology and Bioengineering, 2008
- Shear stress analysis of mammalian cell suspensions for prediction of industrial centrifugation and its verificationBiotechnology and Bioengineering, 2006
- The use of laboratory centrifugation studies to predict performance of industrial machines: Studies of shear-insensitive and shear-sensitive materialsBiotechnology and Bioengineering, 2000