Mitotic drivers—inhibitors of the Aurora B Kinase
Open Access
- 3 February 2009
- journal article
- review article
- Published by Springer Nature in Cancer and Metastasis Reviews
- Vol. 28 (1-2) , 185-195
Abstract
In this article we review the basis for current anti-mitotic, anti-cancer, therapy and the potential for Aurora B kinase inhibitors as a new differentiated class of agents—“mitotic drivers”. We review the current understanding of Aurora B inhibition from basic cell biology to inhibitors currently undergoing clinical trials.Keywords
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