A Cysteine Protease Inhibitor Protects Dogs from Cardiac Damage during Infection byTrypanosoma cruzi
Open Access
- 1 December 2005
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 49 (12) , 5160-5161
Abstract
Cruzain is an essential cysteine protease ofTrypanosoma cruziand a therapeutic target for Chagas' disease. Eight dogs were infected withT. cruzi; three were treated with an inhibitor of cruzain, K777, for 14 days. Treatment with K777 abrogated myocardial damage byT. cruzi, as documented by histopathological lesion scores and serum troponin I levels.Keywords
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