ABCB1 polymorphisms are associated with cyclosporine-induced nephrotoxicity and gingival hyperplasia in renal transplant recipients
- 11 August 2012
- journal article
- pharmacogenetics
- Published by Springer Nature in European Journal of Clinical Pharmacology
- Vol. 69 (3) , 385-393
Abstract
There is a great deal of controversy regarding the clinical impact of genetic variants in patients receiving cyclosporine (CsA) as immunosuppressant therapy. We have investigated the effect of polymorphisms in the CYP3A and ABCB1 genes on CsA pharmacokinetics, acute rejection incidence and drug-related side effects in renal transplant recipientsKeywords
This publication has 43 references indexed in Scilit:
- The new CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with an increased risk of delayed graft function and worse renal function in cyclosporine-treated kidney transplant patientsPharmacogenetics and Genomics, 2012
- Genetic and Clinical Determinants of Early, Acute Calcineurin Inhibitor-Related NephrotoxicityTransplantation, 2012
- Effect of CYP3A and ABCB1 Single Nucleotide Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Calcineurin Inhibitors: Part IIClinical Pharmacokinetics, 2010
- Effect of CYP3A and ABCB1 Single Nucleotide Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Calcineurin Inhibitors: Part IClinical Pharmacokinetics, 2010
- CYP3A7, CYP3A5, CYP3A4, and ABCB1 Genetic Polymorphisms, Cyclosporine Concentration, and Dose Requirement in Transplant RecipientsTherapeutic Drug Monitoring, 2008
- Role ofMDR1gene polymorphisms in gingival overgrowth induced by cyclosporine in transplant patientsJournal of Periodontal Research, 2008
- Association of four DNA polymorphisms with acute rejection after kidney transplantationTransplant International, 2008
- Cyp3A4, Cyp3A5, and MDR-1 genetic influences on tacrolimus pharmacokinetics in renal transplant recipientsPharmacogenetics and Genomics, 2006
- The influence of CYP3A gene polymorphisms on cyclosporine dose requirement in renal allograft recipientsKidney International, 2006
- Clinical Pharmacokinetics of CyclosporinClinical Pharmacokinetics, 1986