PLATELET MONOAMINE OXIDASE ACTIVITY IN PATIENTS WITH HUNTINGTON'S DISEASE
Authors:
- 28 June 1987
- journal article
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 14 (6) , 547-550
Abstract
SUMMARY: 1. Platelet monoamine oxidase (MAO) activity was investigated in 30 patients with Huntington's disease and compared with the activity in a control group.2. Significantly elevated activity was found in the patients (P < 0.05; t‐test) when same sex contrasts were carried out to account for the well known influence of sex on MAO activity.3. The mean MAO activity in male patients was 23.5±6.0 nmol/mg protein per h and female patients was 29.5 ± 8.9 nmol/mg protein per h using tyramine as the substrate.4. The possible influence of environmental factors on the results is discussed.Keywords
This publication has 13 references indexed in Scilit:
- Platelet monoamine oxidase activity and cigarette smokingJournal of Affective Disorders, 1982
- Low platelet monoamine oxidase activity in cigarette smokersLife Sciences, 1981
- Mental Symptoms in Huntington's Disease and a Possible Primary Aminergic Neuron LesionScience, 1980
- Blood Monoamine Metabolism in Huntington's DiseaseArchives of General Psychiatry, 1980
- Platelet monoamine oxidase activity in Huntington's chorea.Journal of Neurology, Neurosurgery & Psychiatry, 1978
- Substrate- and inhibitor-related characteristics of human platelet monoamine oxidaseBiochemical Pharmacology, 1977
- Dopamine is a monoamine oxidase B substrate in manNature, 1977
- UPTAKE OF DOPAMINE AND 5-HYDROXYTRYPTAMINE BY PLATELETS FROM PATIENTS WITH HUNTINGTON'S CHOREAThe Lancet, 1977
- PLASMA UPTAKE OF DOPAMINE AND 5-HYDROXYTRYPTAMINE AND PLASMA-CATECHOLAMINE LEVELS IN PATIENTS WITH HUNTINGTON'S CHOREAThe Lancet, 1974
- AGEING, MONOAMINES, AND MONOAMINE-OXIDASE LEVELSThe Lancet, 1972