The release of prostaglandins and rabbit aorta contracting substance (RCS) from rabbit spleen and its antagonism by anti‐inflammatory drugs
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Open Access
- 1 May 1972
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 45 (1) , 37-47
Abstract
Summary: . Slices of rabbit spleen generate rabbit aorta contracting substance (RCS) and a prostaglandin of the E series when they are vibrated or stirred. . The release of both substances is increased by arachidonic acid and inhibited by aspirin‐like drugs. . When the spleen effluent containing RCS and prostaglandin E is incubated for a further 3 min, the prostaglandin concentration increases and the RCS concentration declines. . RCS may therefore be an unstable intermediate in the biosynthesis of prostaglandins.Keywords
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