Penetration of peroxidase into peripheral nerve fibers
Authors:
- 1 January 1973
- journal article
- research article
- Published by Wiley in Journal of Anatomy
- Vol. 136 (1) , 1-13
Abstract
Penetration of macromolecules into living peripheral nerve was studied in vivo and in vitro using horse‐radish peroxidase. Peroxidase penetrates the epi‐ and perineurium and is sequestered in the Schwann cell body. It then is apparent in the incisures (clefts) of Schmidt‐Lanterman and the paranodal loops. After prolonged incubation the marker appears in the adaxonal Schwann cytoplasm and periaxonal space. It then is visualized inside the axon within vesicles and agranular endoplasmic reticulum both at the node and internodal regions. More rapid penetration occurs at the node of Ranvier than at the internodal region.Keywords
This publication has 13 references indexed in Scilit:
- Penetration of ruthenium red into peripheral nerve fibersThe Anatomical Record, 1972
- Ruthenium red and violet. II. Fine structural localization in animal tissuesThe Anatomical Record, 1971
- MICROPEROXIDASEJournal of Cell Biology, 1971
- Cytochemical studies of protein transport in the nervous systemPhilosophical Transactions of the Royal Society of London. B, Biological Sciences, 1971
- ISOLATION OF THE PERIAXONAL SPACE OF THE CENTRAL MYELINATED NERVE FIBER WITH REGARD TO THE DIFFUSION OF PEROXIDASEJournal of Histochemistry & Cytochemistry, 1969
- Movements in the Myelin Schwann Sheath of the Vertebrate AxonNature, 1969
- Acetylcholinesterase Transport in the Central and Peripheral Nervous Tissue: the Role of Tubules in the Enzyme TransportNature, 1968
- Autoradiographic studies of uridine incorporation in peripheral nerve of the newt, TriturusJournal of Morphology, 1968
- Penetration of Labelled Amino Acids into the Peripheral Nerve Fibre from Surrounding Body Fluidst1968
- THF EARLY STAGES OF ABSORPTION OF INJECTED HORSERADISH PEROXIDASE IN THE PROXIMAL TUBULES OF MOUSE KIDNEY: ULTRASTRUCTURAL CYTOCHEMISTRY BY A NEW TECHNIQUEJournal of Histochemistry & Cytochemistry, 1966