Synthesis of Branched Monodisperse Oligoethylene Glycols and 19F MRI-Traceable Biomaterials through Reductive Dimerization of Azides

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Abstract
Multifunctionalized and branched M-OEGs represent valuable PEGylation agents, linkers and scaffolds in biomedicine. However, the tedious synthesis limited their availability and application. We herein present an azides reductive dimerization method for convenient synthesis of aza-M-OEGs and derivatives, which provides an easy access to a variety of multifunctionalized and branched M-OEGs in 1 step. With this method, hexa-arm M-OEGs with 54 symmetrical fluorines were synthesized in 2 steps as a water soluble, self-assemble, 19F MRI sensitive and biocompatible dendritic biomaterial。
Funding Information
  • Ministry of Science and Technology of the People's Republic of China (2018YFA0704000)
  • National Natural Science Foundation of China (81625011)
  • Chinese Academy of Sciences (QYZDY-SSW-SLH018)

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