KIFCI, a novel putative prognostic biomarker for ovarian adenocarcinomas: delineating protein interaction networks and signaling circuitries
Open Access
- 12 May 2014
- journal article
- research article
- Published by Springer Nature in Journal of Ovarian Research
- Vol. 7 (1) , 53
Abstract
Amplified centrosomes in cancers are recently garnering a lot of attention as an emerging hub of diagnostic, prognostic and therapeutic targets. Ovarian adenocarcinomas commonly harbor supernumerary centrosomes that drive chromosomal instability. A centrosome clustering molecule, KIFC1, is indispensable for the viability of extra centrosome-bearing cancer cells, and may underlie progression of ovarian cancers.Keywords
This publication has 28 references indexed in Scilit:
- Molecular profiling supports the role of epithelial-to-mesenchymal transition (EMT) in ovarian cancer metastasisJournal of Ovarian Research, 2013
- STRING v9.1: protein-protein interaction networks, with increased coverage and integrationNucleic Acids Research, 2012
- Induction of robust de novo centrosome amplification, high-grade spindle multipolarity and metaphase catastrophe: a novel chemotherapeutic approachCell Death & Disease, 2012
- Proper Organization of Microtubule Minus Ends Is Needed for Midzone Stability and CytokinesisCurrent Biology, 2010
- Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomesGenes & Development, 2008
- The utility of MAS5 expression summary and detection call algorithmsBMC Bioinformatics, 2007
- Screening for ovarian cancer in the general populationBest Practice & Research Clinical Obstetrics & Gynaecology, 2006
- Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction NetworksGenome Research, 2003
- The Human Genome Browser at UCSCGenome Research, 2002
- Gene Expression Omnibus: NCBI gene expression and hybridization array data repositoryNucleic Acids Research, 2002