Increased proteinase inhibitor-9 (PI-9) and reduced granzyme B in lung cancer: Mechanism for immune evasion?
Authors:
- Violet MukaroVMViolet Mukaro
- David MoffatDMDavid Moffat
- David MeredithDMDavid Meredith
- Sandra HodgeSHSandra Hodge
- 1 July 2012
- journal article
- research article
- Published by Elsevier in Lung Cancer
- Vol. 77 (1) , 38-45
Abstract
No abstract availableKeywords
This publication has 24 references indexed in Scilit:
- Role of apoptosis resistance in immune evasion and metastasis of colorectal cancerWorld Journal of Gastrointestinal Oncology, 2010
- Expression Pattern of Immune Suppressive Cytokines and Growth Factors in Oesophageal Adenocarcinoma Reveal a Tumour Immune Escape‐promoting MicroenvironmentScandinavian Journal of Immunology, 2008
- Lung CancerNew England Journal of Medicine, 2008
- The granzyme B inhibitor proteinase inhibitor 9 (PI9) is expressed by human mast cellsEuropean Journal of Immunology, 2005
- Low Lung Function and Incident Lung Cancer in the United StatesArchives of internal medicine (1960), 2003
- Epidemiology of Lung Cancer*Chest, 2003
- Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system?Blood, 2002
- Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumorsProceedings of the National Academy of Sciences, 2001
- The Granzyme B Inhibitor, PI-9, Is Present in Endothelial and Mesothelial Cells, Suggesting That It Protects Bystander Cells during Immune ResponsesCellular Immunology, 2001
- Mechanisms of immune suppression in patients with head and neck cancer: Influence on the immune infiltrate of the cancerInternational Journal of Cancer, 1996