Structural Differences between Two Types of "Heavy Chain" Disease Proteins and Myeloma Globulins of Corresponding Types

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Abstract
Structural differences between two antigenic types (designated C and Z) of γ-globulins, both of low molecular weight, produced in "Heavy chain" disease are revealed by their relative susceptibilities to enzymatic degradation by papain and the nature of the cleavage products. Corresponding structural differences exist between the respective type C and type Z myeloma γ 2 -globulins. These structural differences are tentatively assigned to the H-chains, and more specifically to the portion of the H-chain contained in the fast-moving (F) fragment of papain-treated γ 2 -globulins.

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