The iPLA2γ is identified as the membrane potential sensitive phospholipase in liver mitochondria
- 20 July 2015
- journal article
- Published by Wiley in FEBS Letters
- Vol. 589 (18) , 2367-2371
Abstract
Previous reports from our lab identified a mitochondrial calcium‐independent phospholipase A2 activity that is activated when the mitochondrial membrane potential is decreased. This activity was demonstrated to influence occurrence of the permeability transition. Originally, this activity was ascribed to the iPLA2β protein. Recently, both iPLA2β and iPLA2γ knock out mice have been generated. It has been shown by others that the iPLA2γ plays a significant role in progression of the permeability transition. In this paper, using the iPLA2β and iPLA2γ knock out mice we show that the membrane potential sensitive activity is the iPLA2γ.Keywords
Funding Information
- Ellie Kovalcik Research Foundation
- Ohio Northern University
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