Hookworm infections: Reappraising the evidence for a role of neutrophils in light of NETosis
Open Access
- 6 February 2022
- journal article
- review article
- Published by Wiley in Parasite Immunology
- Vol. 44 (6) , e12911
Abstract
In Hookworm infection, neutrophils have long had the image of the villain, being recruited to the site of larval migration because of damage but participating themselves in tissue injury. With recent developments in neutrophil biology, there is an increasing body of evidence for the role of neutrophils as effector cells in hookworm immunity. In particular, their ability to release extracellular traps, or neutrophil extracellular traps (NETs), confer neutrophils a larvicidal activity. Here, we review recent evidence in this nascent field and discuss the avenue for future research on NETs/hookworm interactions.Keywords
Funding Information
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (PR00P3_193084)
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