S6K1 phosphorylation-dependent degradation of Mxi1 by β-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer
Authors:
Open Access
- 1 January 2018
- journal article
- research article
- Published by Ivyspring International Publisher in Theranostics
- Vol. 8 (5) , 1286-1300
Abstract
Rationale: Mxi1 is regarded as a potential tumor suppressor protein that antagonizes the transcriptional activity of proto-oncogene Myc. However, the clinical significances and underlying mechanisms by which Mxi1 is regulated in lung cancer remain poorly understood.Keywords
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