Direct single-nucleotide resolution sequencing of DNA 5-methylcytosine using engineered DNA methyltransferase-mediated CMD-seq

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Abstract
Utilizing the newly identified M.MedI-N377K methyltransferase, we developed a novel method of CMD-seq for the stoichiometric detection of 5mC in DNA at single-nucleotide resolution.
Funding Information
  • National Natural Science Foundation of China (22207090, 22277093)
  • Fundamental Research Funds for the Central Universities (2042024kf1045)

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