Developments of Combretastatin A-4 Derivatives as Anticancer Agents

Authors:
  • YSY. Shan Shan
    Y. Shan Shan
  • JZJ. Zhang
    J. Zhang
  • ZLZ. Liu
    Z. Liu
  • MWM. Wang
    M. Wang
  • YDY. Dong
    Y. Dong
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Abstract
Tubulin protein is one of several members of a small family of globular proteins. It offers a potential target for anticancer drug design and development. Combretastatin A-4 (CA-4) is a potent anticancer and antiangiogenesis natural substance isolated from Combretum caffrum. Modifications on the CA-4 structure have led to a great number of novel CA-4 derivatives as potent tubulin inhibitors and high cytotoxic anticancer agents is becoming an interesting field, leading to a breakthrough in the treatment of cancer. In this review, the recent developments of novel CA-4 derivatives via the modifications on the A- and B-ring and the double bond as anticancer agents are discussed.