Disrupting the ArcA Regulatory Network Amplifies the Fitness Cost of Tetracycline Resistance in Escherichia coli
Open Access
- 23 February 2023
- journal article
- research article
- Published by American Society for Microbiology in mSystems
- Vol. 8 (1) , e0090422
Abstract
Antimicrobial resistance (AMR) is projected to be the cause of >10 million deaths annually by 2050. While efforts to find new potent antibiotics are effective, they are expensive and outpaced by the rate at which new resistant strains emerge.Keywords
Funding Information
- HHS | NIH | National Institute of Allergy and Infectious Diseases (R01AI141953, R01AI128215)
- National Science Foundation (DBI-1565166, IIBR-2042948)
This publication has 105 references indexed in Scilit:
- Clinically Relevant Mutant DNA Gyrase Alters Supercoiling, Changes the Transcriptome, and Confers Multidrug ResistancemBio, 2013
- Conserved small protein associates with the multidrug efflux pump AcrB and differentially affects antibiotic resistanceProceedings of the National Academy of Sciences, 2012
- Phenotypic Landscape of a Bacterial CellCell, 2011
- Sublethal Antibiotic Treatment Leads to Multidrug Resistance via Radical-Induced MutagenesisMolecular Cell, 2010
- An ABC transport system that maintains lipid asymmetry in the Gram-negative outer membraneProceedings of the National Academy of Sciences, 2009
- Systematic and integrative analysis of large gene lists using DAVID bioinformatics resourcesNature Protocols, 2008
- Overflow Metabolism in Escherichia coli during Steady-State Growth: Transcriptional Regulation and Effect of the Redox RatioApplied and Environmental Microbiology, 2006
- Integrating high-throughput and computational data elucidates bacterial networksNature, 2004
- Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction NetworksGenome Research, 2003
- Antimicrobial activity of psychotropic drugsInternational Journal of Antimicrobial Agents, 2000