Mutational status of IGHV is the most reliable prognostic marker in trisomy 12 chronic lymphocytic leukemia
Authors:
- Pietro BulianPBPietro Bulian
- Riccardo BombenRBRiccardo Bomben
- Michele Dal BoMBMichele Dal Bo
- Antonella ZucchettoAZAntonella Zucchetto
- Francesca Maria RossiFRFrancesca Maria Rossi
- Massimo DeganMDMassimo Degan
- Federico PozzoFPFederico Pozzo
- Tamara BittoloTBTamara Bittolo
- Annalisa ChiarenzaACAnnalisa Chiarenza
- 27 July 2017
- journal article
- Published by Ferrata Storti Foundation (Haematologica) in Haematologica
- Vol. 102 (11) , e443-e446
Abstract
Trisomy 12 is a recurrent cytogenetic abnormality that occurs in 15–20% of Chronic Lymphocytic Leukemia (CLL).[1][1],[2][2] Within the hierarchical model proposed by Döhner et al .,[3][3] trisomy 12 CLL (tris12 CLL) carry an intermediate prognostic risk, with median overall survival (OS) and timeKeywords
This publication has 15 references indexed in Scilit:
- Second Cancers and Richter Transformation Are the Leading Causes of Death in Patients With Trisomy 12 Chronic Lymphocytic LeukemiaClinical Lymphoma Myeloma and Leukemia, 2015
- A high proportion of cells carrying trisomy 12 is associated with a worse outcome in patients with chronic lymphocytic leukemiaHematological Oncology, 2015
- Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutationsBlood, 2014
- Genetic lesions associated with chronic lymphocytic leukemia chemo-refractorinessBlood, 2014
- Integration of automated morphological features resolves a distinct group of atypical chronic lymphocytic leukemias with chromosomal aberrationsLeukemia Research, 2014
- CD49d Is the Strongest Flow Cytometry–Based Predictor of Overall Survival in Chronic Lymphocytic LeukemiaJournal of Clinical Oncology, 2014
- CD49d is overexpressed by trisomy 12 chronic lymphocytic leukemia cells: evidence for a methylation-dependent regulation mechanismBlood, 2013
- Two main genetic pathways lead to the transformation of chronic lymphocytic leukemia to Richter syndromeBlood, 2013
- Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute–Working Group 1996 guidelinesBlood, 2008
- Chronic lymphocytic leukaemia profiled for prognosis using a fluorescence in situ hybridisation panelBritish Journal of Haematology, 2006