Natural History of Heroin-Associated Nephropathy

Authors:
  • TRT. K. Sreepada Rao
    T. K. Sreepada Rao
  • ANAnthony D. Nicastri
    Anthony D. Nicastri
  • EFEli A. Friedman
    Eli A. Friedman

Abstract
Of 14 black heroin addicts with massive proteinuria, 12 manifested a typical syndrome including edema, hypoalbuminemia and hypercholesterolemia. Renal biopsies obtained in 13 patients showed focal and segmental glomerular sclerosis in 11, typically (seven of 11 patients) associated with focal glomerular deposition of IgM and β1C/β1A globulin.

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