Acquired expression of CblQ367P in mice induces dysplastic myelopoiesis mimicking chronic myelomonocytic leukemia
Authors:
Open Access
- 13 April 2017
- journal article
- Published by American Society of Hematology in Blood
- Vol. 129 (15) , 2148-2160
Abstract
Key Points: Acquired expression of CblQ367P induces sustained proliferation of myelomonocytes, multilineage dysplasia, and splenomegaly resembling CMML. Combined inhibition of PI3K and JAK2 efficiently suppressed the growth of CblQ367P-induced CMML cells.Keywords
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