Antimicrobial Evaluation of Chlorophyll-Containing Nettle Extract Both in Free Form and Incorporated into Poly-3-Hydroxybutyrate
Authors:
- Polina M. TyubaevaPolina M. Tyubaeva
- Ivetta A. VaryanIVIvetta A. Varyan
- Sergei I. ObydennyiSOSergei I. Obydennyi
- Vasily A. MerzlikinVMVasily A. Merzlikin
- Svetlana G. KarpovaSKSvetlana G. Karpova
- Olga A. GruznovaOGOlga A. Gruznova
- Dmitry V. GruznovDGDmitry V. Gruznov
- Ekaterina N. ShuteevaESEkaterina N. Shuteeva
- Nikolay N. KuvshinchikovNKNikolay N. Kuvshinchikov
- Nikolay I. PopovNPNikolay I. Popov
- Anton V. LobanovALAnton V. Lobanov
- Ivan A. AbramovIAIvan A. Abramov
Open Access
- 17 September 2025
- Vol. 17 (18) , 2507
Abstract
This work is devoted to the electrospinning of biocompatible fibrous matrixes for microbial wound therapy. The problem of treating staphylococcal-infected wounds remains urgent. In this study, we propose a new approach to the use of the chlorophyll (Chl) and poly-3-hydroxybutyrate (PHB) composite system in the treatment of infected wounds. The structure and properties of the electrospun polymer matrix based on PHB modified with various concentrations of Chl was investigated by SEM, confocal microscopy, DSC, EPR. The release rate, fluorescence, and antimicrobial activity of Chl incorporated into PHB were studied. The high efficiency of the developed materials was shown with the participation of laboratory animals.Keywords
This publication has 120 references indexed in Scilit:
- Synthetic-based blended electrospun scaffolds in tissue engineering applicationsJournal of Materials Science, 2022
- Stinging nettle, Urtica dioica L.: botanical, phytochemical and pharmacological overviewPhytochemistry Reviews, 2020
- Recent developments in the synthesis of poly(hydroxybutyrate) based biocompositesBiotechnology Progress, 2019
- Production, ultrasonic extraction, and characterization of poly (3‐hydroxybutyrate) (PHB) usingBacillus megateriumandCupriavidus necatorPolymers for Advanced Technologies, 2018
- Impact of culture conditions on the chlorophyll content of microalgae for biotechnological applicationsWorld Journal of Microbiology and Biotechnology, 2016
- How Can One Controllably Use of Natural ΔpH in Polyelectrolyte Multilayers?Advanced Materials Interfaces, 2016
- Effect of crystallization conditions on the physical properties of a two-layer glassine paper/polyhydroxybutyrate structureJournal of Materials Science, 2015
- Enhancement of the crystallization and thermal stability of polyhydroxybutyrate by polymeric additivesJournal of Thermal Analysis and Calorimetry, 2010
- Scaffold percolative efficiency: in vitro evaluation of the structural criterion for electrospun matsJournal of Materials Science: Materials in Medicine, 2010
- Photodynamic therapy in the treatment of microbial infections: Basic principles and perspective applicationsLasers in Surgery and Medicine, 2006