Development of transgenic rats producing human β-amyloid precursor protein as a model for Alzheimer's disease: Transgene and endogenous APP genes are regulated tissue-specifically
Open Access
- 26 February 2008
- journal article
- Published by Springer Nature in BMC Neuroscience
- Vol. 9 (1) , 28
Abstract
Alzheimer's disease (AD) is a devastating neurodegenerative disorder that affects a large and growing number of elderly individuals. In addition to idiopathic disease, AD is also associated with autosomal dominant inheritance, which causes a familial form of AD (FAD). Some instances of FAD have been linked to mutations in the β-amyloid protein precursor (APP). Although there are numerous mouse AD models available, few rat AD models, which have several advantages over mice, have been generated.Keywords
This publication has 33 references indexed in Scilit:
- Overexpression of APP provides neuroprotection in the absence of functional benefit following middle cerebral artery occlusion in ratsEuropean Journal of Neuroscience, 2007
- A transgenic rat expressing human APP with the Swedish Alzheimer’s disease mutationBiochemical and Biophysical Research Communications, 2007
- Transgenic Modifications of the Rat GenomeTransgenic Research, 2005
- Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the β-amyloid peptide intracellularly in hippocampal and cortical neuronsNeuroscience, 2004
- Genetic background regulates -amyloid precursor protein processing and -amyloid deposition in the mouseHuman Molecular Genetics, 2003
- Transgenesis in rats: Technical aspects and modelsTransgenic Research, 1996
- Differential distribution of amyloid protein precursor immunoreactivity in the rat brain studied by using five different antibodiesJournal of Comparative Neurology, 1994
- Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's diseaseNature, 1991
- Tissue-specific expression of three types of β-protein precursor mRNA: Enhancement of protease inhibitor-harboring types in Alzheimer's disease brainBiochemical and Biophysical Research Communications, 1989
- Superovulation of Immature Rats by Continuous Infusion of Follicle-Stimulating Hormone1Biology of Reproduction, 1988