Expression of specific white adipose tissue genes in denervation‐induced skeletal muscle fatty degeneration
Authors:
- Jean-Paul DulorJDJean-Paul Dulor
- Brigitte CambonBCBrigitte Cambon
- Pierre VigneronPVPierre Vigneron
- Yves ReyneYRYves Reyne
- Jean NouguèsJNJean Nouguès
- Louis CasteillaLCLouis Casteilla
- Francis BacouFBFrancis Bacou
- 13 November 1998
- journal article
- Published by Wiley in FEBS Letters
- Vol. 439 (1-2) , 89-92
Abstract
Denervation of skeletal muscle results in rapid atrophy with loss of contractile mass and/or progressive degeneration of muscle fibers which are replaced to a greater or lesser degree by connective and fatty tissues. In this study, we show that denervated rabbit muscles are transformed into a white adipose tissue, depending on their fiber types. This tissue does express LPL, G3PDH and particularly the ob gene, a white adipose tissue‐specific marker, and does not express the brown adipose tissue molecular marker UCP1 mRNA.Keywords
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