Synergistic interaction between UV and ionizing radiation in wild-type Schizosaccharomyces pombe
Authors:
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in Molecular Genetics and Genomics
- Vol. 164 (1) , 31-37
Abstract
Summary A synergistic effect of combined UV and γ-ray exposure was observed for inactivation of wild-type Schizosaccharomyces pombe. A recombinational repair process, known to be important in restitution of damage induced by both radiations, appears to be involved; a radiation-sensitive mutant defective in this repair pathway showed essentially no synergistic interaction between UV and γ-rays. Recovery from the synergistic effect of pre-exposure in wild-type cells did not display the expected fast γ-recovery and slow UV-recovery kinetics previously observed for regain of resistance to further exposure to the same radiation. Rather, UV-irradiated cells recovered quickly from synergistic inactivation on subsequent γ-exposure, while γ-irradiated cells recovered UV-resistance slowly. Recovery from synergism thus appears to reflect the nature of the second, and not the initial, radiation.Keywords
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