The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice
Authors:
- Steven H. HinrichsSHSteven H. Hinrichs
- R. Kay ReynoldsRRR. Kay Reynolds
- Paul A. LuciwPLPaul A. Luciw
- Gilbert JayGJGilbert Jay
- 1 October 1988
- journal article
- Published by Springer Nature in Nature
- Vol. 335 (6191) , 606-611
Abstract
When the human immunodeficiency virus transactivating gene under the control of the viral regulatory region is introduced into the germline of mice, skin lesions are induced that resemble Kaposi's sarcoma seen in AIDS. Our findings indicate that HIV could play a direct part in causing cancer.Keywords
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