Phase contrast tomography of the mouse cochlea at microfocus x-ray sources
Open Access
- 19 August 2013
- journal article
- conference paper
- Published by AIP Publishing in Applied Physics Letters
- Vol. 103 (8) , 083703
Abstract
We present phase contrast x-ray tomography of functional soft tissue within the bony cochlear capsule of mice, carried out at laboratory microfocus sources with well-matched source, detector, geometry, and reconstruction algorithms at spatial resolutions down to 2 μm. Contrast, data quality and resolution enable the visualization of thin membranes and nerve fibers as well as automated segmentation of surrounding bone. By complementing synchrotron radiation imaging techniques, a broad range of biomedical applications becomes possible as demonstrated for optogenetic cochlear implant research.Keywords
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