Surface characteristics and protein adsorption on combinatorial binary Ti‐M (Cr, Al, Ni) and Al‐M (Ta, Zr) library films
Authors:
- 20 February 2009
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research Part A
- Vol. 92A (2) , 521-532
Abstract
Systematic studies of protein adsorption onto metallic biomaterial surfaces are generally lacking. Here, combinatorial binary library films with compositional gradients of Ti1‐xCrx, Ti1‐xAlx, Ti1‐xNix and Al1‐xTax, (0 1‐yZry (0 < y 2 and Al2O3 preferentially forming on the binary film surfaces. Correspondingly, protein adsorption onto these films closely correlated with their surface oxide fractions. Aluminum deposited as either a constant‐composition film or as part of a binary library consistently adsorbed the least amount of albumin and fibrinogen, with alumina‐enrichment of the surface oxide correlating with this adsorption. Overall, this combinatorial materials approach coupled with high‐throughput surface analytical methods provides an efficient method of screening potential metallic biomaterials that may enable as well systematic studies of surface properties driving protein adsorption on these metal / metal oxide systems. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010Keywords
This publication has 52 references indexed in Scilit:
- Bring That Pioneering Spirit Back! A 25-Year Perspective on the Vascular StentCardioVascular and Interventional Radiology, 2007
- Quantification of the kinetics and thermodynamics of protein adsorption using atomic force microscopyJournal of Biomedical Materials Research Part A, 2005
- Integration of Combinatorial Synthesis, Rapid Screening, and Computational Modeling in Biomaterials DevelopmentMacromolecular Rapid Communications, 2004
- Economical Sputtering System To Produce Large-Size Composition-Spread Libraries Having Linear and Orthogonal Stoichiometry VariationsChemistry of Materials, 2002
- Electrochemical Studies of the Adsorption Behavior of Serum Proteins on TitaniumLangmuir, 2000
- Ellipsometric Study of Bovine Serum Albumin Adsorbed onto Ti/TiO2 ElectrodesJournal of Colloid and Interface Science, 1999
- Electrochemical Studies of the Adsorption Behavior of Bovine Serum Albumin on Stainless SteelLangmuir, 1999
- Protein interaction with tantalum: Changes with oxide layer and hydroxyapatite at the interfaceJournal of Biomedical Materials Research, 1992
- Fibrinogen–aluminium interaction: Changes with oxide layer thickness onto metal surfaceJournal of Biomedical Materials Research, 1990
- Enhanced Protein Adsorption at the Solid-Solution Interface: Dependence on Surface ChargeScience, 1973