Effects of a novel arginine methyltransferase inhibitor on T‐helper cell cytokine production
Open Access
- 19 April 2010
- journal article
- Published by Wiley in The FEBS Journal
- Vol. 277 (9) , 2096-2108
Abstract
The protein arginine methyltransferase (PRMT) family of enzymes catalyzes the transfer of methyl groups from S‐adenosylmethionine to the guanidino nitrogen atom of peptidylarginine to form monomethylarginine or dimethylarginine. We created several less polar analogs of the specific PRMT inhibitor arginine methylation inhibitor‐1, and one such compound was found to have improved PRMT inhibitory activity over the parent molecule. The newly identified PRMT inhibitor modulated T‐helper‐cell function and thus may serve as a lead for further inhibitors useful for the treatment of immune‐mediated disease.Structured digital abstract MINT‐7710141: Prmt1 (uniprotkb:Q63009) physically interacts (MI:0915) with nip45 (uniprotkb:O09130) by anti tag coimmunoprecipitation (MI:0007) MINT‐7710127: Prmt1 (uniprotkb:Q63009) physically interacts (MI:0915) with Prmt1 (uniprotkb:Q63009) by anti tag coimmunoprecipitation (MI:0007)Keywords
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