Exosomal miR-21 from tubular cells contributes to renal fibrosis by activating fibroblasts via targeting PTEN in obstructed kidneys
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Open Access
- 1 January 2021
- journal article
- research article
- Published by Ivyspring International Publisher in Theranostics
- Vol. 11 (18) , 8660-8673
Abstract
Rationale: Ureteral obstruction-induced hydronephrosis is associated with renal fibrosis and progressive chronic kidney disease (CKD). Exosome-mediated cell-cell communication has been suggested to be involved in various diseases, including renal fibrosis. However, little is known regarding how exosomes regulate renal fibrosis in obstructed kidneys.Keywords
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