Demonstration of a geometric isomer of bilirubin-IX α in the serum of a hyperbilirubinaemic newborn infant and the mechanism of jaundice phototherapy

Authors:
  • SOS Onishi
    S Onishi
  • KIK Isobe
    K Isobe
  • SIS Itoh
    S Itoh
  • NKN Kawade
    N Kawade
  • SSS Sugiyama
    S Sugiyama
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Abstract
Photobilirubin-IX alpha in the serum of a hyperbilirubinaemic newborn infant was demonstrated for the first time by reversed-phase high-pressure liquid chromatography. The concentrations increased significantly during phototherapy. Corresponding to these changes in the serum, biliary unconjugated bilirubin concentrations increased markedly but photobilirubin-IX alpha was not detected in the bile. Moreover, large amounts of ‘unknown pigment’ that are diazo-negative appeared in the bile during phototherapy.

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