Expeditious Synthesis of a Glycopeptide Library

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Abstract
Short proteoglycan fragments are of great importance for biochemical research. The solid‐phase synthesis of such glycopeptides relies on excessive use of glycosylated amino acids, extended reaction times, and additional post‐assembly deprotection protocols. We employed high‐shear mixing for expedient and equimolar O‐glycopeptide assembly. We further developed a stirring‐based deprotection on the solid support, thus completing the synthesis of a glycopeptide library in a minimal amount of time and purification hurdles.
Funding Information
  • European Commission

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