Steady-State Plasma Concentration Profile of Transdermal Rotigotine: An Integrated Analysis of Three, Open-Label, Randomized, Phase I Multiple Dose Studies
Authors:
- Jan-Peer ElshoffJEJan-Peer Elshoff
- Marina BraunMBMarina Braun
- Jens-Otto AndreasJAJens-Otto Andreas
- Michelle MiddleMMMichelle Middle
- Willi CawelloWCWilli Cawello
- 1 April 2012
- journal article
- research article
- Published by Elsevier in Clinical Therapeutics
- Vol. 34 (4) , 966-978
Abstract
No abstract availableKeywords
This publication has 17 references indexed in Scilit:
- Absorption, Disposition, Metabolic Fate, and Elimination of the Dopamine Agonist Rotigotine in Man: Administration by Intravenous Infusion or Transdermal DeliveryDrug Metabolism and Disposition, 2009
- Influence of domperidone on pharmacokinetics, safety and tolerability of the dopamine agonist rotigotineBritish Journal of Clinical Pharmacology, 2009
- Efficacy of rotigotine for treatment of moderate-to-severe restless legs syndrome: a randomised, double-blind, placebo-controlled trialThe Lancet Neurology, 2008
- Efficacy of rotigotine transdermal system in severe restless legs syndrome: A randomized, double-blind, placebo-controlled, six-week dose-finding trial in EuropeSleep Medicine, 2008
- Efficacy of pramipexole and transdermal rotigotine in advanced Parkinson's disease: a double-blind, double-dummy, randomised controlled trialThe Lancet Neurology, 2007
- Continuous delivery of rotigotine decreases extracellular dopamine suggesting continuous receptor stimulationJournal of Neural Transmission, 2007
- Randomized, blind, controlled trial of transdermal rotigotine in early Parkinson diseaseNeurology, 2007
- Transdermal Administration of Radiolabelled [14C]Rotigotine by a Patch FormulationClinical Pharmacokinetics, 2007
- Frequency of levodopa‐related dyskinesias and motor fluctuations as estimated from the cumulative literatureMovement Disorders, 2001
- Continuous dopamine-receptor stimulation in early Parkinson's diseaseTrends in Neurosciences, 2000