Action of Anionic and Cationic Nerve-Blocking Agents: Experiment and Interpretation
Authors:
- 22 July 1966
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 153 (3734) , 429-432
Abstract
Barbiturates and anesthetics similar to procaine bind to phospholipids in vitro. The former increase the binding of calcium to the phospholipids; the latter decrease it. The data can be correlated with the effects of these drugs on peripheral nerve. The nonpolar portion of the narcotic agents may lie between the lipid chains of the membrane, with the charged region in close approximation to the polar heads of the phospholipids.Keywords
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