Thermo‐triggered and biotinylated biotin‐P(NIPAAm‐co‐HMAAm)‐b‐PMMA micelles for controlled drug release
- 23 April 2008
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research Part A
- Vol. 88A (3) , 814-822
Abstract
Thermosensitive and biotinylated biotin‐poly (N‐isopropylacrylamide‐co‐N‐hydroxymethylacrylamide)‐block‐poly(methyl methacrylate) (biotin‐P(NIPAAm‐co‐HMAAm)‐b‐PMMA) block copolymers were designed and synthesized. The conjugation of biotin molecule with the copolymer as well as the capability of easily functionalizing with ligands for pretargeting approach of the biotinylated multifunctional drug carrier was confirmed by a novel method called capillary electrophoresis immunoassay (CEIA) based on enhanced chemiluminescence (CL) detection. The biotin‐P(NIPAAm‐co‐HMAAm)‐b‐PMMA copolymer was capable of self‐assembling into nanometer‐sized micelle. The anticancer drug methotrexate (MTX), used as a model drug, was loaded in the self‐assembled micelles and the thermo‐triggered release behavior of MTX was investigated. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009Keywords
This publication has 24 references indexed in Scilit:
- “SMART” Drug Delivery Systems: Double-Targeted pH-Responsive Pharmaceutical NanocarriersBioconjugate Chemistry, 2006
- Thermosensitive Y‐Shaped Micelles of Poly(oleic acid‐Y‐N‐isopropylacrylamide) for Drug DeliverySmall, 2006
- Self-assembled thermoresponsive micelles of poly(N-isopropylacrylamide-b-methyl methacrylate)Biomaterials, 2006
- Biodegradable Nanoparticles for Direct or Two-Step Tumor ImmunotargetingBioconjugate Chemistry, 2005
- Recent advances in tumor-targeting anticancer drug conjugatesBioorganic & Medicinal Chemistry, 2005
- Intelligent Crew‐Cut Aggregates Formed by Thermosensitive Block Copolymers and Their Multiple MorphologiesMacromolecular Bioscience, 2005
- Super pH-Sensitive Multifunctional Polymeric MicelleNano Letters, 2005
- Stimuli-Responsive Supramolecular Assemblies of Linear-Dendritic CopolymersJournal of the American Chemical Society, 2004
- Surface-engineered nanoparticles for multiple ligand couplingBiomaterials, 2003
- Polymeric micelles – a new generation of colloidal drug carriersEuropean Journal of Pharmaceutics and Biopharmaceutics, 1999