Clinical study for classification of benign, dysplastic, and malignant oral lesions using autofluorescence spectroscopy
Open Access
- 1 January 2004
- journal article
- clinical trial
- Published by SPIE-Intl Soc Optical Eng in Journal of Biomedical Optics
- Vol. 9 (5) , 940-951
Abstract
Autofluorescence spectroscopy is a noninvasive tool for the detection of alterations in the structural and chemical composition of cells, which may indicate the presence of pathologic tissue.1 2 3 4 Autofluorescence of tissues is produced by several endogenous fluorophores. These include fluorophores from tissue matrix molecules and intracellular molecules like collagen, elastin, keratin, and NADH. The presence of disease changes the concentration of these fluorophores as well as the light scattering and absorption properties of the tissue, due to changes in a.o. blood concentration, nuclear size distribution, epithelial thickness, and collagen content. It is therefore expected that the presence of disease will be identifiably reflected in autofluorescence spectral shape and intensity.Keywords
This publication has 32 references indexed in Scilit:
- PLS‐ANN based classification model for oral submucous fibrosis and oral carcinogenesisLasers in Surgery and Medicine, 2003
- Endoscopic light-induced autofluorescence spectroscopy for the diagnosis of colorectal cancer and adenomaJournal of Photochemistry and Photobiology B: Biology, 2003
- Spectroscopic detection and evaluation of morphologic and biochemical changes in early human oral carcinomaCancer, 2003
- Field change and oral cancer: new evidence for widespread carcinogenesis?International Journal of Oral and Maxillofacial Surgery, 2002
- In vivo autofluorescence spectroscopy of human bronchial tissue to optimize the detection and imaging of early cancersJournal of Biomedical Optics, 2001
- Understanding the contributions of NADH and collagen to cervical tissue fluorescence spectra: Modeling, measurements, and implicationsJournal of Biomedical Optics, 2001
- AUTOFLUORESCENCE GUIDED BIOPSY FOR THE EARLY DIAGNOSIS OF BLADDER CARCINOMAJournal of Urology, 1998
- Detection of dysplasia at colonoscopy using laser-induced fluorescence: a blinded studyGastrointestinal Endoscopy, 1996
- Early genetic changes during upper aerodigestive tract tumorigenesisJournal of Cellular Biochemistry, 1993
- Basic principles of ROC analysisSeminars in Nuclear Medicine, 1978