Epigenetic change in e-cardherin and COX-2 to predict chronic periodontitis
Open Access
- 4 November 2010
- journal article
- Published by Springer Nature in Journal of Translational Medicine
- Vol. 8 (1) , 110
Abstract
DNA methylation of certain genes frequently occurs in neoplastic cells. Although the cause remains unknown, many genes have been identified with such atypical methylation in neoplastic cells. The hypermethylation of E-Cadherin and Cyclooxygenase 2 (COX-2) in chronic inflammation such as chronic periodontitis may demonstrate mild lesion/mutation epigenetic level. This study compares the hypermethylation status of E-Cadherin and COX-2 genes which are often found in breast cancer patients with that in chronic periodontitis.Keywords
This publication has 33 references indexed in Scilit:
- Gender Differences in the Relationship Between Periodontal Disease, Tooth Loss, and AtherosclerosisStroke, 2004
- Aberrant CpG Island Hypermethylation of Chronic Gastritis, in Relation to Aging, Gender, Intestinal Metaplasia, and Chronic InflammationThe American Journal of Pathology, 2003
- E-cadherin expression in primary carcinomas of the breast and its distant metastasesBreast Cancer Research, 2003
- Epigenetic gene silencing in cancer initiation and progressionCancer Letters, 2003
- Gender differences in HLA phenotype frequencies found in German patients with generalized aggressive periodontitis and chronic periodontitisOral Microbiology and Immunology, 2002
- Periodontal risk assessment, diagnosis and treatment planningPeriodontology 2000, 2001
- Fortnightly review: Periodontitis for medical practitionersBMJ, 1998
- Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis.Proceedings of the National Academy of Sciences, 1994
- Modern Radiographic Methods in the Diagnosis of Periodontal DiseaseAdvances in Dental Research, 1993
- Periodontal Findings in Adult TwinsJournal of Periodontology, 1991