New neo-lignan from Acanthopanax senticosus with protein tyrosine phosphatase 1B inhibitory activity
Authors:
- 16 September 2015
- journal article
- research article
- Published by Springer Nature in Archives of Pharmacal Research
- Vol. 40 (11) , 1265-1270
Abstract
New neo-lignan, (7S, 8R)-3-hydroxyl-4-methoxyl-balanophonin (1), together with seven known compounds (2–8) were isolated from the EtOAc-soluble extract of Acanthopanax senticosus. The structure of the new neo-lignan was elucidated with spectroscopic and physico-chemical analyses. All the isolates were evaluated for in vitro inhibitory activity against PTP1B, VHR and PP1. Among them, the new compound (1) was found to exhibit selective inhibitory activity on PTP1B with IC50 value 15.2 ± 1.4 µM.Keywords
Funding Information
- Project Sponsored by Special Funds of Medical Programms of Jilin Province (YYZX201240YYZX201240 and 20150101225JC)
- Jilin Shizandra Development & Industrialization Engineering Research Center (2013G020)
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