Pharmacological basis for the therapy of pain and inflammation with nonsteroidal anti-inflammatory drugs
Open Access
- 1 January 2000
- journal article
- review article
- Published by Springer Nature in Arthritis Research & Therapy
- Vol. 2 (5) , 379-85
Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) belong to the most frequently used drugs. The discovery of an inducible isoform of cyclo-oxygenase (COX-2) has led to an intensive worldwide search and the introduction of selective COX-2 inhibitors. In this review, recent advances in understanding the mechanism of action of NSAIDs and, in this context, clinical findings on NSAID-induced gastrointestinal side effects are summarized. This knowledge is important for the effective treatment of pain and inflammation, as well as for preventing serious and sometimes lethal gastrointestinal side effects.Keywords
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