Viruslike Particles in Malaria Parasites

Authors:
  • JTJ. A. Terzakis
    J. A. Terzakis
  • JVJ. P. Vanderberg
    J. P. Vanderberg
  • MWM. M. Weiss
    M. M. Weiss
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Abstract
The ultrastructural appearance of viruslike particles in several malaria parasites at different times in sporogony is described in detail. Emphasis is placed on particle size, 42-52 nm, density and the presence or absence of a geometric configuration of particle aggregations in Plasmodium berghei ookinetes, and P. gallinaceum early oocysts. This particle appearance is compared with that noted in later oocysts of P. berghei, P. gallinaceum, and P. cynomolgi bastianelli and with negatively-stained particles obtained by fractionation of Anopheles stephensi midguts heavily infected by P. berghei oocysts. Although particles are dispersed in later oocysts, particle size and shape is similar to that noted in the aggregates in early forms. Aggregations of particles in a geometric configuration in ookinetes and early oocysts is associated with a particle of smaller diameter and the absence of a limiting membrane or envelope. This suggests an incomplete or nascent virus particle form. The observations of such particles in malaria and other blood parasites is compared with the present findings.