Silicon‐Based Chemistry: An Original and Efficient One‐Step Approach to [18F]‐Nucleosides and [18F]‐Oligonucleotides for PET Imaging
- 10 February 2011
- journal article
- research article
- Published by Wiley in Chemistry – A European Journal
- Vol. 17 (11) , 3096-3100
Abstract
Take it eaSi! Nucleosides, dinucleotides, and one oligonucleotide, all modified by click chemistry, have for the first time been directly and very efficiently labeled with 18F by using a silicon-based, one-step approach that opens the way for the development of a new class of positron emission tomography (PET) tracers (see graphic).Keywords
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