Synthesis of New bis 1-Substituted 1H-Tetrazoles via Efficient Heterocyclizations from Symmetric Dianilines, Methyl Orthoester, and Sodium Azide
Authors:
- Julio C. Flores-ReyesJulio C. Flores-Reyes
- Roberto E. Blanco-CarapiaRoberto E. Blanco-Carapia
- Alfredo López-OlveraAlfredo López-Olvera
- Perla Islas-JácomePerla Islas-Jácome
- Yizrell Medina-MartínezYizrell Medina-Martínez
- Mónica A. Rincón-GuevaraMónica A. Rincón-Guevara
- Ilich A. IbarraIlich A. Ibarra
- Leticia Lomas-RomeroLeticia Lomas-Romero
- Eduardo González-ZamoraEduardo González-Zamora
- Alejandro Islas-JácomeAlejandro Islas-Jácome
Open Access
- 14 November 2019
- conference paper
- Published by MDPI AG in Proceedings
- Vol. 41 (1) , 26
Abstract
The synthesis and characterization of three new bis 1-substituted 1H-tetrazoles are described. Two products were synthesized in a single step via a direct heterocyclization of primary amines, methyl orthoester (trymethyl orthoformate), and sodium azide in 30% and 91% yields, respectively. Besides, another one was prepared via a three-step synthetic strategy: SNAr (32%), nitro-group reduction (66%), and primary amine heterocyclization (83%), yielding 18%, overall. The aim behind the synthesis of new tetrazole-containing products is to construct novel MOF-like structures to evaluate their gas capture properties (CO2, CO, and SO2) under relative humidity conditions.Keywords
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