Drug-Delivery by Ion-Exchange. Part I: Ester Pro-Drugs of Propranolol
Authors:
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 13 (9-11) , 2017-2031
Abstract
The syntheses of some ester pro-drugs of propranolol, suitable for complexing with cationic ion-exchange resins, are described. These include the n-acyl esters ranging from O-acetyl to O-decanoyl propranolol and the bulky pivaloyl ester. Conditions are presented which enable the isolation of the O-acyl compound, free from the competing N-acyl product, to be accomplished. Spectroscopic properties are described to confirm identity and the optimisation of high-performance liquid chromatographic separations, to enable resolution of mixed esters and degradation products, is described.Keywords
This publication has 17 references indexed in Scilit:
- Erratum to: Quantitative relationships between structure and pharmacokinetics of beta-adrenoceptor blocking agents in manJournal of Pharmacokinetics and Biopharmaceutics, 1984
- Cardioselectivity of .beta.-adrenoceptor blocking agents. 2. Role of the amino group substituentJournal of Medicinal Chemistry, 1983
- Derivatives of .beta.-adrenergic antagonists: N-nitrosopropranolol and N-hydroxypropranolol and its aldonitroneJournal of Medicinal Chemistry, 1983
- Sustained-Release Drug Delivery System I: Coated Ion-Exchange Resin System for Phenylpropanolamine and Other DrugsJournal of Pharmaceutical Sciences, 1981
- Ring-hydroxylated propranolol: synthesis and .beta.-receptor antagonist and vasodilating activities of the seven isomersJournal of Medicinal Chemistry, 1981
- Synthesis of Propranolol Mustard as a Possible Lung-Specific Antitumor AgentJournal of Pharmaceutical Sciences, 1980
- 4-Hydroxypropranolol and its glucuronide after single and long-term doses of propranololClinical Pharmacology & Therapeutics, 1980
- Synthesis and biological activity of spin-labeled analogs of biotin, hexamethonium, decamethonium, dichlorisoproterenol, and propranololJournal of Medicinal Chemistry, 1975
- .beta.-Adrenergic blocking agents. VI. Pronethalol and propranolol analogs with alkyl substituents in the alkanol side chainJournal of Medicinal Chemistry, 1969
- .beta.-Adrenergic blocking agents. II. Propranolol and related 3-amino-1-naphthoxy-2-propanolsJournal of Medicinal Chemistry, 1968