Efficacy of metformin treatment in polycystic ovary syndrome
Authors:
Open Access
- 20 November 2021
- journal article
- research article
- Published by University of Maribor in Acta Medico-Biotechnica
- Vol. 6 (2) , 13-20
Abstract
Metformin is an oral antidiabetic drug with potentially beneficial effects in patients with polycystic ovary syndrome (PCOS). Different pharmacological responses to met- formin have been reported in PCOS patients, which may be attributable to various clinical, biochemical, genetic and other factors. Here, we have outlined a short review of the results from current clinical studies on metformin efficacy in PCOS patients. Additionally, preliminary results from a retrospective pharmacogenetic study by our group on a sample of Slovene PCOS patients are presented. Pharmacogenetics is an emerging science that should pro- vide options for individualized medicine, the future of healthcare.Keywords
This publication has 30 references indexed in Scilit:
- A Common 5′-UTR Variant in MATE2-K Is Associated With Poor Response to MetforminClinical Pharmacology & Therapeutics, 2011
- Efficacy of metformin therapy in adolescent girls with androgen excess: relation to sex hormone–binding globulin and androgen receptor polymorphismsFertility and Sterility, 2010
- Systemic and local effects of metformin administration in patients with polycystic ovary syndrome (PCOS): relationship to the ovulatory responseHuman Reproduction, 2010
- Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metforminPharmacogenetics and Genomics, 2009
- The Effects of Genetic Polymorphisms in the Organic Cation Transporters OCT1, OCT2, and OCT3 on the Renal Clearance of MetforminClinical Pharmacology & Therapeutics, 2009
- Efficacy predictors for metformin and clomiphene citrate treatment in anovulatory infertile patients with polycystic ovary syndromeFertility and Sterility, 2009
- Identification of multidrug and toxin extrusion (MATE1 and MATE2-K) variants with complete loss of transport activityJournal of Human Genetics, 2009
- The follicular excess in polycystic ovaries, due to intra-ovarian hyperandrogenism, may be the main culprit for the follicular arrestHuman Reproduction Update, 2004
- Determination of a common genetic variant of luteinizing hormone using DNA hybridization and immunoassaysClinical Endocrinology, 1998
- Hypersecretion of luteinizing hormone and the polycystic ovary syndromeHuman Reproduction, 1993