Multiple modes of cytoplasmic dynein regulation
- 29 February 2012
- journal article
- Published by Springer Nature in Nature Cell Biology
- Vol. 14 (3) , 224-230
Abstract
In performing its multiple cellular functions, the cytoplasmic dynein motor is subject to complex regulation involving allosteric mechanisms within the dynein complex, as well as numerous extramolecular interactions controlling subcellular targeting and motor activity. Recent work has distinguished high- and low-load regulatory modes for cytoplasmic dynein, which, combined with a diversity of targeting mechanisms, accounts for a very broad range of functions.Keywords
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