DETERMINATION OF METFORMIN IN CULTIVATED PLANT SPECIES AND SOIL BY LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY
- 29 October 2010
- journal article
- research article
- Published by Taylor & Francis in Journal of Liquid Chromatography & Related Technologies
- Vol. 33 (18) , 1630-1639
Abstract
A liquid chromatographic-mass spectrometry (LC-MS/MS) method for the determination of metformin in cultivated plant species and soil is described. Plant samples (barley, barley-leaf, carrot, etc.) or soil were homogenized with an extraction solution of ammonium acetate/formic acid and centrifuged. The supernatant was clean-up with a solid phase extraction column, filtered, and injected into the LC/MS-MS. The limits of quantification were 30 ng/g for metformin.Keywords
This publication has 11 references indexed in Scilit:
- Spectrophotometric and HPLC determinations of anti-diabetic drugs, rosiglitazone maleate and metformin hydrochloride, in pure form and in pharmaceutical preparationsEuropean Journal of Medicinal Chemistry, 2009
- Successful Treatment of Severe Lactic Acidosis Caused by a Suicide Attempt with a Metformin OverdoseThe Kaohsiung Journal of Medical Sciences, 2009
- HPLC-UV determination of metformin in human plasma for application in pharmacokinetics and bioequivalence studiesJournal of Pharmaceutical and Biomedical Analysis, 2008
- Simultaneous determination of metformin and gliclazide in human plasma by liquid chromatography–tandem mass spectrometry: application to a bioequivalence study of two formulations in healthy volunteersJournal of Mass Spectrometry, 2005
- Severe metformin intoxication with lactic acidosis in an adolescentEuropean Journal of Pediatrics, 2005
- Rapid determination of metformin in human plasma using ion-pair HPLCJournal of Pharmaceutical and Biomedical Analysis, 2003
- Aquatic environmental assessment of the top 25 English prescription pharmaceuticalsWater Research, 2002
- HPLC-DAD determination of Metformin in human plasma using derivatization with p-nitrobenzoyl chloride in a biphasic systemMicrochemical Journal, 2001
- Clinical Pharmacokinetics of MetforminClinical Pharmacokinetics, 1996
- Diabetes and diabetes risk factors in second- and third-generation Japanese Americans in Seattle, WashingtonDiabetes Research and Clinical Practice, 1994